> Randomized controlled trials have also shown that exercise or psychotherapy are valid treatment options The research on exercise is rather inconclusive (most

> Randomized controlled trials have also shown that exercise or psychotherapy are valid treatment options The research on exercise is rather inconclusive (mostly because it's hard to placebo-control exercise, but see e.g. [1] for an interesting attempt), and I don't know of any trials that demonstrate the validity of switching away from a working depression treatment. The chances of success are generally not great when trying a new depression treatment (~30% for the first one, decreasing with each failed treatment [2]), so I'm not convinced that the validity alluded to here actually translates into any actionable advice in the context of this study. [1] http://www.ncbi.nlm.nih.gov/pubmed/21037212 http://www.ncbi.nlm.nih.gov/pubmed/21037212 [2] http://www.edc.gsph.pitt.edu/stard/ http://www.edc.gsph.pitt.edu/stard/