It depends on the design, but you can build something using the panels (+ gypsum board) as walls and floors, with almost no other structural members, at least f

It depends on the design, but you can build something using the panels (+ gypsum board) as walls and floors, with almost no other structural members, at least for residential. For insulation, the standard approach seems to be using rigid panels on the outside, either rock wool or foam. This stuff is a good bit more expensive than stick built construction, so I figure they count the expense of outside-only insulation (vs. batts or cellulose between the studs) is just a cost that goes with it. If you're building high-end, you may as well insulate high-end.