Canadian starting a startup in the US: I haven't launched my startup yet, and I reside in Canada. I've never been employed in the US. I'd like my startup's HQ

Canadian starting a startup in the US: I haven't launched my startup yet, and I reside in Canada. I've never been employed in the US. I'd like my startup's HQ to be based in the US. What's the best way for a Canadian to set up base and launch in the US?