While it is challenging to build a Django integration, there are some options for working with RethinkDB. You can check this StackOverflow answer for a starting

While it is challenging to build a Django integration, there are some options for working with RethinkDB. You can check this StackOverflow answer for a starting base: http://stackoverflow.com/questions/28001980/how-to-setup-rethinkdb-with-django http://stackoverflow.com/questions/28001980/how-to-setup-ret... Jorge Silva (@thejsj) also wrote this demo app to show how you could pair MySQL with RethinkDB when using Django: https://github.com/thejsj/django-and-rethinkdb https://github.com/thejsj/django-and-rethinkdb