GRAS is a food additive designation and does apply ONLY to ingestion. The pharmacology of an inhaled substance can be completely different than that of an inge

GRAS is a food additive designation and does apply ONLY to ingestion. The pharmacology of an inhaled substance can be completely different than that of an ingested one. The same goes for intravenous, topical and subcutaneous as well. Just because something is safe for one method of delivery does not mean it is safe for another. GRAS is applicable and continually updated regarding ingestion, but it does NOT apply to inhalation. Edit: side note, the database of additives approved in pharmaceutical products is specific to route of delivery and ,for the US, can be found in the FDA's inactive ingredients database: http://www.accessdata.fda.gov/scripts/cder/iig/index.Cfm http://www.accessdata.fda.gov/scripts/cder/iig/index.Cfm