4 ms·
Nicotine users just can't catch a break. Based on the real subject of the article, diacetyl, I'm surprised the chemical has not been regulated by now. Here is
by binarymax 11y ago
Nicotine users just can't catch a break.
Based on the real subject of the article, diacetyl, I'm surprised the chemical has not been regulated by now.
Here is the federal register snippet [0]
§184.1278 Diacetyl.
(a) Diacetyl (C4H6O2, CAS Reg. No. 431-03-8) is a clear yellow to yellowish green liquid with a strong pungent odor. It is also known as 2,3-butanedione and is chemically synthesized from methyl ethyl ketone. It is miscible in water, glycerin, alcohol, and ether, and in very dilute water solution, it has a typical buttery odor and flavor.
(b) The ingredient meets the specifications of the Food Chemicals Codex, 3d Ed. (1981), p. 368, which is incorporated by reference. Copies are available from the National Academy Press, 2101 Constitution Ave. NW., Washington, DC 20418, or available for inspection at the National Archives and Records Administration (NARA). For information on the availability of this material at NARA, call 202-741-6030, or go to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html http://www.archives.gov/federal_register/code_of_federal_reg....
(c) In accordance with §184.1(b)(1), the ingredient is used in food with no limitation other than current good manufacturing practice. The affirmation of this ingredient as generally recognized as safe (GRAS) as a direct human food ingredient is based upon the following current good manufacturing practice conditions of use:
(1) The ingredient is used as a flavoring agent and adjuvant as defined in §170.3(o)(12) of this chapter.
(2) The ingredient is used in food at levels not to exceed current good manufacturing practice.
(d) Prior sanctions for this ingredient different from the uses established in this section do not exist or have been waived.
[48 FR 51907, Nov. 15, 1983]
[0] http://www.ecfr.gov/cgi-bin/text-idx?rgn=div5&node=21:3.0.1.1.14#se21.3.184_11278 http://www.ecfr.gov/cgi-bin/text-idx?rgn=div5&node=21:3.0.1....
- mrob 11y agoIt's not nicotine users specifically at risk here, because unflavored nicotine liquids are available, as well as flavored zero-nicotine liquids. Flavorings seem like an unnecessary risk to me -- the dangers of diacetyl have been known for several years so it doesn't surprise me that other flavorings can also damage lungs. None of them have anywhere close to the level of safety research as the nicotine or the carrier liquids (propylene glycol or glycerol). Even before this research the risk:benefit ratio for flavorings looked very dubious.
- notlisted 11y agoI'm not clear if you are being sarcastic, but note the GRAS (generally recognized as safe), for ingestion at least...
- mrob 11y agoIf you ever stand near a typical vaper, you'll notice they use very high concentrations of flavoring. Any food with this much flavoring would probably be considered inedible. I think very strong flavoring is popular to overcome desensitization caused by frequent use.
- binarymax 11y agoI am not being sarcastic. That entry hasn't changed in the FR since 1983. "Generally recognized as safe" is out of date and the chemical needs another regulatory review and update.
- daveguy 11y agoFR is a log of all regulations and you are referencing an old GRAS notification. GRAS is valid and up to date FOR INGESTION ONLY. Here is the most current information on GRAS food additives (not pharma additives) from the FDA: http://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/ http://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/ Here is the inactive ingredients database for approved pharmaceutical additives which depends on route of administration: http://www.accessdata.fda.gov/scripts/cder/iig/index.Cfm http://www.accessdata.fda.gov/scripts/cder/iig/index.Cfm
- daveguy 11y agoGRAS is a food additive designation and does apply ONLY to ingestion. The pharmacology of an inhaled substance can be completely different than that of an ingested one. The same goes for intravenous, topical and subcutaneous as well. Just because something is safe for one method of delivery does not mean it is safe for another. GRAS is applicable and continually updated regarding ingestion, but it does NOT apply to inhalation. Edit: side note, the database of additives approved in pharmaceutical products is specific to route of delivery and ,for the US, can be found in the FDA's inactive ingredients database: http://www.accessdata.fda.gov/scripts/cder/iig/index.Cfm http://www.accessdata.fda.gov/scripts/cder/iig/index.Cfm