Your discussion of the motivation for the metformin research is intriguing - thanks. NCI has funded human trials based on human epidemiological studies to furt

Your discussion of the motivation for the metformin research is intriguing - thanks. NCI has funded human trials based on human epidemiological studies to further examine metformin's possible impact on cancer: (April 2015) http://www.cancer.gov/about-cancer/causes-prevention/research/metformin http://www.cancer.gov/about-cancer/causes-prevention/researc... Calorie restriction support was recently undermined by a NIA study. The conflict between the NIA and Wisconsin study is summarized by TIME here: http://healthland.time.com/2012/08/29/want-to-live-longer-dont-try-caloric-restriction/ http://healthland.time.com/2012/08/29/want-to-live-longer-do... The teams are supposed to be working on a joint study to resolve their differing results. EDIT: I have seen Dr. Mosley's BBC documentaries and they pre-date the recent CRON results. His HIIT segment is also very interesting. Not dismissing any of it - just not the slam-dunk that it seemed at first.