4 ms·

It looks like this is just a correlation based on historical availability of Tylenol and related compounds in developed countries. It's not obvious from skimmin

by cbhl 11y ago

It looks like this is just a correlation based on historical availability of Tylenol and related compounds in developed countries. It's not obvious from skimming that the author identifies the cause by which Tylenol allegedly causes Alzheimer's, which would be crucial in prevention (e.g. by changing Tylenol) and/or finding a cure.

rbritton 11y ago
This is far from my area of expertise, so please correct me if I'm wrong, but the second section looks like it does exactly that: PA-metabolising enzymes are localised in the synaptic areas of the frontal cortex and hippocampus, where F-AD lesions arise. The initiating chemical lesions in liver poisoning comprise covalent binding of a highly reactive product of PA metabolism to proteins; similar events are believed to occur in brain, where alterations in the antigenic profiles of cerebral proteins activate the microglia. β-Amyloid forms, and, like PA itself, induces nitric oxide synthase. Peroxynitrite modifies cerebral proteins by nitrating tyrosine residues, further challenging the microglia and exacerbating the amyloid cascade. Spontaneous reinnervation, N-acetyl cysteine administration and tyrosine supplementation may attenuate the early stages of F-AD development.
bradleyjg 11y ago
I've heard that if acetaminophen were in front of the FDA today it probably wouldn't be approved at all, and certainly not over the counter -- because of the narrow therapeutic range and the risk of liver damage.
dragonwriter 11y ago
> It looks like this is just a correlation based on historical availability of Tylenol and related compounds in developed countries. That correlation is drawn, as is a correlation between Alzheimer's (and Alzheimer's-like symptoms) and symptoms potentially related to a side effect of a prior drug for which PA is the active metabolite, which was replaced by PA in the market. > It's not obvious from skimming that the author identifies the cause by which Tylenol allegedly causes Alzheimer's, Both the CYTOCHROME P450 and PA AND F-AD: EARLY-STAGE CEREBRAL INJURY sections identify particular mechanisms by which PA may cause or contribute to the progression.

by cbhl 11y ago

rbritton 11y ago

This is far from my area of expertise, so please correct me if I'm wrong, but the second section looks like it does exactly that: PA-metabolising enzymes are localised in the synaptic areas of the frontal cortex and hippocampus, where F-AD lesions arise. The initiating chemical lesions in liver poisoning comprise covalent binding of a highly reactive product of PA metabolism to proteins; similar events are believed to occur in brain, where alterations in the antigenic profiles of cerebral proteins activate the microglia. β-Amyloid forms, and, like PA itself, induces nitric oxide synthase. Peroxynitrite modifies cerebral proteins by nitrating tyrosine residues, further challenging the microglia and exacerbating the amyloid cascade. Spontaneous reinnervation, N-acetyl cysteine administration and tyrosine supplementation may attenuate the early stages of F-AD development.

bradleyjg 11y ago

I've heard that if acetaminophen were in front of the FDA today it probably wouldn't be approved at all, and certainly not over the counter -- because of the narrow therapeutic range and the risk of liver damage.

dragonwriter 11y ago

> It looks like this is just a correlation based on historical availability of Tylenol and related compounds in developed countries. That correlation is drawn, as is a correlation between Alzheimer's (and Alzheimer's-like symptoms) and symptoms potentially related to a side effect of a prior drug for which PA is the active metabolite, which was replaced by PA in the market. > It's not obvious from skimming that the author identifies the cause by which Tylenol allegedly causes Alzheimer's, Both the CYTOCHROME P450 and PA AND F-AD: EARLY-STAGE CEREBRAL INJURY sections identify particular mechanisms by which PA may cause or contribute to the progression.