The only domains python and C# really overlap is web with ASP.NET and Python web frameworks - and here portability used to be the determining factor. Python us

The only domains python and C# really overlap is web with ASP.NET and Python web frameworks - and here portability used to be the determining factor. Python use cases are completely different from C# - Python is all about fast iteration and prototyping, REPL, interfacing to native libraries etc. C# is about static typing and all that it implies. F# is slightly closer to Python with REPL and type inference but still on the C# side of spectrum.