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...and so can an old microscope. Betzig invented PALM, which was a cool idea. This isn't. The lattice light sheet is a combination of a great idea Betzig didn't
by throwaway_41673 11y ago
...and so can an old microscope. Betzig invented PALM, which was a cool idea. This isn't. The lattice light sheet is a combination of a great idea Betzig didn't invent (light sheet microscopy) with another great idea Betzig didn't invent (structured illumination microscopy). The engineering is well done, but the fundamental idea is crap: the two techniques don't combine in an elegant way, and interfere with each other's strengths. What Betzig did exceptionally well with this paper was parlay a star-studded author list and some fancy surface-rendered time lapse movies into an extremely high-impact paper, despite a mediocre underlying accomplishment.