Well, given our tremendous struggle with rational design of novel protein nanostructures, my point was that we should avoid that difficulty by designing some li

Well, given our tremendous struggle with rational design of novel protein nanostructures, my point was that we should avoid that difficulty by designing some ligand-binding proteins only once, then assemble those into the larger structures that we desire. Of course, knowing all protein (structural) phenotypes for all amino acid sequences up to length=100 would also be nice... but seems unlikely something we can work towards due to constraints of scarce universe.