5 ms·

I could see something like this being very useful for preventing deaths due to contaminated party drugs. If it works.

jacquesm 11y ago
That's not the sort of test you'll be able to do with this device. Pills tend to be opaque for one, and the contamination may very well be too small to detect anyway.
- OopsCriticality 11y ago
  I agree that this device wouldn't work for that assay, but the opacity of the pills isn't a factor: the optical bench is too small and the illumination will be too low to do anything worthwhile.
  - jacquesm 11y ago
    What about: handedness of the molecules, variations in density (the surface of pills tends to be compressed)?
    - OopsCriticality 11y ago
      You're right that chirality is important and this thing isn't able to probe that. As to what I'll broadly call "sample prep", you're right again to point out how that is a critical consideration. So you're double right. Operating in NIR does give deeper penetration, which is one of the reasons to consider NIR spectroscopy in an application; I'd guess that this thing operates somewhere in the 700–900nm range, but I admittedly don't know what kind of interrogation volume that gives for a pill. So, I'm wrong to casually dismiss opacity of the target. That stems from a bias due to a background in instrumentation (meaning, I start my thinking there). I think I'm still right though to think that instrumentation is a bigger problem than sample prep for this device, which I didn't do a good job in stating earlier.
      - jacquesm 11y ago
        Fair enough. And I should have done a (much) better job at indicating why I thought this instrument would not be suitable.
OopsCriticality 11y ago
Raman spectroscopy is used in pharma manufacturing and law enforcement to inspect pharma evidence in the field, but compact Raman spectrometers are a couple of orders of magnitude more expensive than this consumer device. Also, you really need an analytical chemist to interpret the data. Raman is hard. NIR spectroscopy, which is what this product uses, isn't very sensitive and wouldn't be a good choice to look for trace contaminants even on quality instrumentation.

That's not the sort of test you'll be able to do with this device. Pills tend to be opaque for one, and the contamination may very well be too small to detect anyway.

OopsCriticality 11y ago
I agree that this device wouldn't work for that assay, but the opacity of the pills isn't a factor: the optical bench is too small and the illumination will be too low to do anything worthwhile.
- jacquesm 11y ago
  What about: handedness of the molecules, variations in density (the surface of pills tends to be compressed)?
  - OopsCriticality 11y ago
    You're right that chirality is important and this thing isn't able to probe that. As to what I'll broadly call "sample prep", you're right again to point out how that is a critical consideration. So you're double right. Operating in NIR does give deeper penetration, which is one of the reasons to consider NIR spectroscopy in an application; I'd guess that this thing operates somewhere in the 700–900nm range, but I admittedly don't know what kind of interrogation volume that gives for a pill. So, I'm wrong to casually dismiss opacity of the target. That stems from a bias due to a background in instrumentation (meaning, I start my thinking there). I think I'm still right though to think that instrumentation is a bigger problem than sample prep for this device, which I didn't do a good job in stating earlier.
    - jacquesm 11y ago
      Fair enough. And I should have done a (much) better job at indicating why I thought this instrument would not be suitable.

OopsCriticality 11y ago

Raman spectroscopy is used in pharma manufacturing and law enforcement to inspect pharma evidence in the field, but compact Raman spectrometers are a couple of orders of magnitude more expensive than this consumer device. Also, you really need an analytical chemist to interpret the data. Raman is hard. NIR spectroscopy, which is what this product uses, isn't very sensitive and wouldn't be a good choice to look for trace contaminants even on quality instrumentation.