In the case of this HN submission, they're the same thing. From what I can gather, Adsuck is essentially just a DNS forwarder that sends NX DOMAIN for blacklist

In the case of this HN submission, they're the same thing. From what I can gather, Adsuck is essentially just a DNS forwarder that sends NX DOMAIN for blacklisted domains but forwards the DNS requests for all other DNS lookups. So "spoof" is a little misleading since it's actually doing the job of a normal DNS forwarder - albeit tuned with privacy in mind. So I think it's fair to say this method could more accurately be defined as "block[ing] domains" rather than "spoofing DNS". However I'd welcome a correction if I'm wrong.