Will the difficulties they face when they're younger impact their grades and in turn impact which colleges will accept them? If yes, optimize for that not to h

Will the difficulties they face when they're younger impact their grades and in turn impact which colleges will accept them? If yes, optimize for that not to happen. If no, optimize for difficulty. It's probably impossible to predict what will happen on an individual level, these sorts of statistics are useful mostly on a populational level. Good luck.