For me: communication - This is really hard and sometimes harder in person. loneliness - I'm married, wife is a homemaker so I get to see her all the time,

For me: communication - This is really hard and sometimes harder in person. loneliness - I'm married, wife is a homemaker so I get to see her all the time, this isn't an issue for me but i can see it could be for some. isolation - Exactly, that is the point, sweet quiet. timezones - This is only not an issue when it isn't. Otherwise the problem with timezones makes no difference whether the people are remote or in an office, the problem is the timezone difference itself. discipline, After several years in the military early on, this isn't an issue either.