You can use the guix command line tool and let it talk to a remote guix-daemon. I would not know how to set this up on a Mac, but Guix is in fact designed such

You can use the guix command line tool and let it talk to a remote guix-daemon. I would not know how to set this up on a Mac, but Guix is in fact designed such that the command line tool is separate from the daemon. I'm using this feature to provide users of our scientific compute clusters with a way to manage their software on all cluster nodes. The Guix tool on the nodes connects to one central guix-daemon. That's all GNU/Linux, though. I don't know if this could work on a Mac. You could ask on guix-devel@gnu.org or on #guix at freenode.