There's also Lilypond (lots of Guile) and Gimp (a little bit of Guile), which are both pretty well-known projects. Guix itself is a large project. GDB has Gui

There's also Lilypond (lots of Guile) and Gimp (a little bit of Guile), which are both pretty well-known projects. Guix itself is a large project. GDB has Guile scripting support as well. The website could feature a few more projects.