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Perhaps they mean synthetic genes from the major market players. It's definitely not 10% of all DNA synthesis. For example, oligos produced on microarrays alo
by skosuri 11y ago
Perhaps they mean synthetic genes from the major market players. It's definitely not 10% of all DNA synthesis. For example, oligos produced on microarrays alone can produce this much DNA on a single chip. I'm assuming they mean assembled, sequence verified DNA. For that, I'm not sure where they are getting their numbers.
- adenadel 11y agoI assumed that they meant unique sequence. The oligo pools for microarrays really only need to be synthesized a single time and a single oligo can be present multiple times. Synthesizing 100M bp is really trivial if you amplify any bit of DNA :)
- skosuri 11y agoI wasn't talking about copies of the same sequence. Agilent for instance makes 1M oligo arrays, and you can get these at 200nt each with arbitrary sequence. That's 200M bp of synthetic DNA spec'd to design on a single chip.
- bcanton 11y agoYep, thanks for clarifying. We're using the figures quoted by gene synthesis firms to get the 10%. That makes sense because we're buying 100Mbp of gene synthesis:) We buy lots more DNA in other forms (chip-synthesized oligos etc.).