Sorry for the late reply, but yes, the biggest difference is the ability to be politically aware, and learning how to keep your team out of the politics as much

Sorry for the late reply, but yes, the biggest difference is the ability to be politically aware, and learning how to keep your team out of the politics as much as possible so they can get the job done. Getting stuff done at any organization is more about finding out who the stakeholders are and getting as many to neutral or positive as possible so that you can execute. But in a large politicized organization it requires significantly more political navigating and energy compared to say a startup where usually a good idea can win even if the person isn't that great at the politics.