Xperf or WPA is an excellent tool for holistically analysing your application (and all the other applications running on your machine at the same time). We do u

Xperf or WPA is an excellent tool for holistically analysing your application (and all the other applications running on your machine at the same time). We do use that tool for looking at lots of different things: file IO, thread contention, server performance, etc. But for a single client running, I find VTune to be excellent. Its very well integrated into Visual Studio, and provides a number of different perf experiments that you can run to isolate the causes of your bottlenecks. VTune is commercial, but you can use Very Sleepy for a free alternative.