4 ms·
Throwing things at the wall to see what sticks is precisely how drugs were developed before the 1970s. It's called phenotypic screening, and it worked quite wel
by ksenzee 11y ago
Throwing things at the wall to see what sticks is precisely how drugs were developed before the 1970s. It's called phenotypic screening, and it worked quite well. There's an argument to be made (Derek Lowe makes it here [0]) that it worked better than the modern method of target-based drug discovery.
[0] http://blogs.sciencemag.org/pipeline/archives/2012/04/16/phenotypic_screenings_comeback http://blogs.sciencemag.org/pipeline/archives/2012/04/16/phe...
- tsotha 11y agoI see what he's saying, but I wonder. There has to be a point of diminishing returns. Maybe we've already discovered the easy ones, and yet more mass screening won't turn up much.