Yes those are all important parts in the development of cancer. But you have to take into account the tools that cancer has to take advantage of when it comes t

Yes those are all important parts in the development of cancer. But you have to take into account the tools that cancer has to take advantage of when it comes to invasiveness and proliferation. DNA instability is the root cause which results in incorrect signalling, cell cycle progression, cell morphology, and immune system evasion. But take angiogenesis, an extremely important tool for a developing embryo, and how ubiquitous it is for a growing tumor. But we can go farther and consider the factors that influence the guidance of a cell during development. Accutane or Isotretinoin is very similar in structure to retinoic acid, a guidance molecule in the posterior embryo. Consequently isotretinoin causes birth defects. Interestingly isoretinoin has also been implicated as an anti-cancer treatment. Thalidomide, which also interrupts proper development has also been used as an anti-cancer treatment. My point isn't to dispute the importance of DNA damage and gene expression profile changes, but rather to emphasize the importance of metastasis and its apparent parallels with embryonic development since metastasis is the main reason (sans leukemias) why cancer has such a high lethality.