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Also somewhat tangential, but completely related, I'm curious peeps in biotech, what are your guys' opinions on Oxford Nanopore MinION? IMHO, MinION is even mo
by noname123 11y ago
Also somewhat tangential, but completely related, I'm curious peeps in biotech, what are your guys' opinions on Oxford Nanopore MinION?
IMHO, MinION is even more exciting than Theranos in that it is a real-time USB-stick sequencer that sequence a whole complete genome or the metagenomics inside a person's blood or guts (currently < 6hrs, in matters of minutes for detecting viral genomes in blood such as ebola since you can feed the sequencing data in a real-time pipeline to a BLAST to the viral genome reference database). Due to the early access program, there are quite a few papers published on its protocol attesting its pro's and con's.
Illumnia, the current king of genome sequencing has more its stock price than 10x since it has beaten out its NGS competitors as the "sequencer de-jure".
MinION, IMO like PacBio won't beat Illumina ever in read-error rate; however, can open up a new market in sequencing patient samples in clinical settings - which may be an order of magnitude bigger than academic sequencing. However, the argument against it is that there are already RT-PCR blood tests that can detect reliably in clinical settings different viral infections; also sequencing may be real-time, but you still need technicians to do the sample prep (e.g., extract the DNA and prep it for the NGS adapters).
Would love to hear people's opinions on the viability of nanopore sequencing here.