3 ms·

The full text of the study is paywalled here: http://www.cell.com/cancer-cell/abstract/S1535-6108%2815%2900334-7 http://www.cell.com/cancer-cell/abstract/S1535-

by jobu 11y ago

The full text of the study is paywalled here: http://www.cell.com/cancer-cell/abstract/S1535-6108%2815%2900334-7 http://www.cell.com/cancer-cell/abstract/S1535-6108%2815%290... Fortunately the summary there has some useful information: "rVAR2 (recombinant malarial protein VAR2CSA) fused to diphtheria toxin or conjugated to hemiasterlin compounds strongly inhibits in vivo tumor cell growth and metastasis" Anyone know how they're attaching those toxins/compounds to the malarial protein?

trhway 11y ago
>how they're attaching those toxins/compounds to the malarial protein? curious for the same, googled "protein fused to toxin" and it brought like this https://en.wikipedia.org/wiki/Immunotoxin https://en.wikipedia.org/wiki/Immunotoxin and http://www.ncbi.nlm.nih.gov/pubmed/8105849 http://www.ncbi.nlm.nih.gov/pubmed/8105849