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You can always export your raw data from 23andMe and plug it into third party (and I guess foreign) services that will give you some health info. Of course you

You can always export your raw data from 23andMe and plug it into third party (and I guess foreign) services that will give you some health info. Of course you should probably approach the results with some skepticism. I know someone who found out she had a gene that causes an early and very aggressive cancer and now can take pre-emptive measures that quite likely will save her life.

davorb 11y ago
> I know someone who found out she had a gene that causes an early and very aggressive cancer and now can take pre-emptive measures that quite likely will save her life. Do you mind if I ask what service she used for this?
- duked 11y ago
  Not sure what the poster above used but I personally was faced with the same issue. I got my raw data from 23me and used https://www.promethease.com/ https://www.promethease.com/. I think you can do it for free yourself with the desktop version http://www.snpedia.com/index.php/Promethease/Desktop http://www.snpedia.com/index.php/Promethease/Desktop but it takes longer anyway I found some useful information from it but it's to be take with a grain of salt
- disantlor 11y ago
  I believe she used promethease.com as the other commenter mentioned (which is what I used too). She took the result to the doctor and they did a more thorough test for that specific gene to confirm (which is probably advisable with any serious/negative result before panic).
robbiep 11y ago
It is very likely that someone finding this information would have been able to discover it by looking at their family tree. Serious genetic diseases do have a small de novo rate but by and large are already there just being passed down
- anon1mous 11y ago
  Wrong. For one people used to die a lot younger, many genetic defects will only kill an older, weaker human. For two the environment is different, e.g. many more cancerogens in and around us. Just have a look at the cancer rates. A middle aged man in US today has a 70% chance of getting cancer during his lifetime.
  - robbiep 11y ago
    Sorry mate, what? The op said a friend discovered they had a genetic mutation that lead to an increased risk of cancer. There are several conditions that do this: multiple endocrine neoplasia (types 1 and 2), li fraumeni syndrome (a p53 mutation), familial adenomatous polyposis (apc mutation), hereditary non-polyposis colorectal cancer and a handful of others. All of these present with strong family histories. In fact, patients with APC mutations often have cancer before their 30s. Yet have been successfully passing on this mutation for generations now. If you do not have defective copies of the above (or a small subset of mutations of other regulatory and proto-oncogenes) then you have no greater chance of developing cancer than the next person, lifestyle and virus exposure factors not withstanding. Now I really don't think you have any idea what you're talking about because your two points are at odds with each other: you first state that we are living longer, and defects 'will kill older, weaker humans'. Bullshit. Your next point, that cancer rates are higher now than at some indeterminate point in the past, is also bullshit and out of context: if we are living longer, then of course we are going to get cancer. But this has no bearing on our genetic susceptibility to cancer over a certain age. In fact, there are no known genetic mutations that predispose to cancer later in life; all the syndromes predispose to cancer early. I can only suppose you are trolling very hard, and hence hiding behind 'anon1mous'
xirdstl 11y ago
I didn't realize you could get the raw data. I looked a bit on their website and didn't find anything indicating you can. What format(s) will they export?
- disantlor 11y ago
  Not really sure about formatting options but you can get at it here: https://www.23andme.com/you/download/ https://www.23andme.com/you/download/
- deleted 11y ago
  [deleted]

davorb 11y ago

> I know someone who found out she had a gene that causes an early and very aggressive cancer and now can take pre-emptive measures that quite likely will save her life. Do you mind if I ask what service she used for this?

duked 11y ago
Not sure what the poster above used but I personally was faced with the same issue. I got my raw data from 23me and used https://www.promethease.com/ https://www.promethease.com/. I think you can do it for free yourself with the desktop version http://www.snpedia.com/index.php/Promethease/Desktop http://www.snpedia.com/index.php/Promethease/Desktop but it takes longer anyway I found some useful information from it but it's to be take with a grain of salt
disantlor 11y ago
I believe she used promethease.com as the other commenter mentioned (which is what I used too). She took the result to the doctor and they did a more thorough test for that specific gene to confirm (which is probably advisable with any serious/negative result before panic).

robbiep 11y ago

It is very likely that someone finding this information would have been able to discover it by looking at their family tree. Serious genetic diseases do have a small de novo rate but by and large are already there just being passed down

anon1mous 11y ago
Wrong. For one people used to die a lot younger, many genetic defects will only kill an older, weaker human. For two the environment is different, e.g. many more cancerogens in and around us. Just have a look at the cancer rates. A middle aged man in US today has a 70% chance of getting cancer during his lifetime.
- robbiep 11y ago
  Sorry mate, what? The op said a friend discovered they had a genetic mutation that lead to an increased risk of cancer. There are several conditions that do this: multiple endocrine neoplasia (types 1 and 2), li fraumeni syndrome (a p53 mutation), familial adenomatous polyposis (apc mutation), hereditary non-polyposis colorectal cancer and a handful of others. All of these present with strong family histories. In fact, patients with APC mutations often have cancer before their 30s. Yet have been successfully passing on this mutation for generations now. If you do not have defective copies of the above (or a small subset of mutations of other regulatory and proto-oncogenes) then you have no greater chance of developing cancer than the next person, lifestyle and virus exposure factors not withstanding. Now I really don't think you have any idea what you're talking about because your two points are at odds with each other: you first state that we are living longer, and defects 'will kill older, weaker humans'. Bullshit. Your next point, that cancer rates are higher now than at some indeterminate point in the past, is also bullshit and out of context: if we are living longer, then of course we are going to get cancer. But this has no bearing on our genetic susceptibility to cancer over a certain age. In fact, there are no known genetic mutations that predispose to cancer later in life; all the syndromes predispose to cancer early. I can only suppose you are trolling very hard, and hence hiding behind 'anon1mous'

xirdstl 11y ago

I didn't realize you could get the raw data. I looked a bit on their website and didn't find anything indicating you can. What format(s) will they export?

disantlor 11y ago
Not really sure about formatting options but you can get at it here: https://www.23andme.com/you/download/ https://www.23andme.com/you/download/
deleted 11y ago
[deleted]