Ideally we can find a way to engineer proteins that have known shape and conformations and binding, without having to increase our knowledge about protein foldi

Ideally we can find a way to engineer proteins that have known shape and conformations and binding, without having to increase our knowledge about protein folding or DNA folding. Maybe certain amino acids fold more heuristically-predictably than other amino acids? And ligand binding affinity is much simpler to engineer compared to the computationally expensive molecular dynamics simulation of protein folding. There's probably other options here, too.