3 ms·
My original post is correct. APOE 4/4 is sensitive to dietary fat; high fat diets cause large LDL [0]. Further, fat causes atherosclerosis in APOE 4/4 individua
by gavazzy 11y ago
My original post is correct. APOE 4/4 is sensitive to dietary fat; high fat diets cause large LDL [0]. Further, fat causes atherosclerosis in APOE 4/4 individuals more quickly than others [1].
It would make sense that APOE 4/4 would have this effect, because it is the "defective" form of APOE. Individuals with APOE 4/4 do not clear oxidized fats from the brain as quickly as APOE 2 or 3 individuals.
[0] http://jn.nutrition.org/content/134/10/2517.full http://jn.nutrition.org/content/134/10/2517.full
[1] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674716/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674716/
- gavazzy 11y agoUpdate to previous post: A study on diet and APOE genotype showed that fat content affects APOE 4 and APOE 2 or 3 people differently. "No diet can be recommended unequivocally without knowing more about those being targeted. Even though a MUFA-rich diet increases LDL size compared with a CHO-rich diet, this effect is dependent on apoE genotypes. Thus, the replacement of a CHO diet by a MUFA diet increases LDL-size in apoE 3/3, whereas it decreases it in apoE 4/3 subjects" http://jn.nutrition.org/content/134/10/2517.full.pdf+html http://jn.nutrition.org/content/134/10/2517.full.pdf+html