4 ms·
The hype is just out of control on this. It's a new tool in the lab that is of some use, but none of these other fantastical claims are anywhere near the real w
by lvs 11y ago
The hype is just out of control on this. It's a new tool in the lab that is of some use, but none of these other fantastical claims are anywhere near the real world, and they may never be. This method suffers the same risks as viral therapies that have also been very difficult to bring to real patients.
- mudil 11y agoMaybe. Maybe not. Viral therapies suffer from one problem: viruses. (They might be infectious, or not. They might be attacked by the immune system or not.) CRISPR technique does not need an external vector.
- timrpeterson 11y agoHow does the cas9 protein get in?
- kbenzle 11y agoBoth protein and guide RNA need to be expressed in the organism, so viral, bacterial or mechanical introduction of DNA is still necessary.
- gww 11y agoCIRSPR requires a method to deliver the nuclease complexes to cellular targets in a living organism. I believe the only methods tried so far used adenoviruses.
- pcrh 11y agoA few recent papers have shown that it can be done by directly introducing the required proteins.