3 ms·

That article is 50 years old. Perhaps this one from 2013: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063972 http://journals.plos.org/plo

That article is 50 years old. Perhaps this one from 2013: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0063972 http://journals.plos.org/plosone/article?id=10.1371/journal.... "21,967 respondents (13.4% weighted) reported lifetime psychedelic use. There were no significant associations between lifetime use of any psychedelics, lifetime use of specific psychedelics (LSD, psilocybin, mescaline, peyote), or past year use of LSD and increased rate of any of the mental health outcomes. Rather, in several cases psychedelic use was associated with lower rate of mental health problems."

thrwyycombinatr 11y ago
But temporary schizophrenia is very common. Cmon guys, this is ridiculous. I've seen it so many times. It literally re-wires your brain. And yes, temporary schizophrenia can be extremely dangerous. This is something no one can argue. I hate pedants.
- throwawaymonoid 11y ago
  Your brain literally re-wires itself constantly. There's no such thing as "temporary schizophrenia." If you're referring to acute psychosis, as you seemingly experienced, then yes it's certainly a possible side effect--though never a permanent one. Bad experiences are usually triggered by an uncomfortable setting, or a dose for which you were not prepared. I'm sorry that was your experience, but concerned your reaction doesn't add to the scientific discussion. LSD increases glutamate and modulates the 5HTA (seratonin) subtypes, as well as having modulatory effects on D2 (dopamine) receptors--it alters conscious processes and lowers the inhibitory threshold of the action potential, allowing "new" neuronal pathways to develop. While we don't know the specific pharmacokinetic MOA, we do know it has a favorable toxicological and therapeutic profile, and that the content of one's hallucinations depend far more on the individual and the setting than the substance. Yes, it can be dangerous. Yes, you can take steps to effectively minimize the danger like you do in every other area of your life (seatbelts? helmets?). Like anything there's a cost-benefit ratio for each individual to consider--are you willing to risk a potentially terrifying experience for a chance at novel insight? I think that's a choice everyone should be able to make for themselves.

thrwyycombinatr 11y ago

But temporary schizophrenia is very common. Cmon guys, this is ridiculous. I've seen it so many times. It literally re-wires your brain. And yes, temporary schizophrenia can be extremely dangerous. This is something no one can argue. I hate pedants.

throwawaymonoid 11y ago
Your brain literally re-wires itself constantly. There's no such thing as "temporary schizophrenia." If you're referring to acute psychosis, as you seemingly experienced, then yes it's certainly a possible side effect--though never a permanent one. Bad experiences are usually triggered by an uncomfortable setting, or a dose for which you were not prepared. I'm sorry that was your experience, but concerned your reaction doesn't add to the scientific discussion. LSD increases glutamate and modulates the 5HTA (seratonin) subtypes, as well as having modulatory effects on D2 (dopamine) receptors--it alters conscious processes and lowers the inhibitory threshold of the action potential, allowing "new" neuronal pathways to develop. While we don't know the specific pharmacokinetic MOA, we do know it has a favorable toxicological and therapeutic profile, and that the content of one's hallucinations depend far more on the individual and the setting than the substance. Yes, it can be dangerous. Yes, you can take steps to effectively minimize the danger like you do in every other area of your life (seatbelts? helmets?). Like anything there's a cost-benefit ratio for each individual to consider--are you willing to risk a potentially terrifying experience for a chance at novel insight? I think that's a choice everyone should be able to make for themselves.