The biggest things for me are: * Setting up several statuses (more than in the default) to reflect backlog, selected, in progress, testing, deployed * Creatin

The biggest things for me are: * Setting up several statuses (more than in the default) to reflect backlog, selected, in progress, testing, deployed * Creating an appropriate board which splits everything into columns by status and rows by user * Setting up a few quick filters to find things like anything which has been in the backlog for more than 6 weeks or bugs which haven't seen activity in the last 48 hours * Integrating GitHub. Being able to kick a ticket over to QA from your commit message is awesome. Beyond that, I mostly focus on stripping out default things to make the workflow simpler. I don't need my software to enforce that I can't move a ticket to deployed straight from in progress, and stripping out those extra rules makes it easier to deal with.