If it's just a matter of speeding up a tight loop, I find numba performs admirably and it's a lot more convenient than Cython. When you need to wrap some c cod

If it's just a matter of speeding up a tight loop, I find numba performs admirably and it's a lot more convenient than Cython. When you need to wrap some c code, or use high-level data structures (that cython handles beautifully with STL integration) that's when it makes sense to drop to Cython.