It really depends on your use case. Cython is more flexible and suitable for libraries, but Numba is easier to write. I elaborated on this in a recent blog post

It really depends on your use case. Cython is more flexible and suitable for libraries, but Numba is easier to write. I elaborated on this in a recent blog post: http://eng.climate.com/2015/04/09/numba-vs-cython-how-to-choose/ http://eng.climate.com/2015/04/09/numba-vs-cython-how-to-cho...