Let me give a (probably very leaky) programming analogy: You have one library, and it solves 1 class of problems. You use a second library on top of it to try

Let me give a (probably very leaky) programming analogy: You have one library, and it solves 1 class of problems. You use a second library on top of it to try and address some bits introduced by library 1. This may well move the core metric needle to get you what you want, but you will undoubtedly incur unforeseen interactions, and additional potential edge cases. When you add the brain into the equation, it removes all of the (comparatively flawless) understanding we have of the system the libraries are running within, and then when you add benzos, one of your libraries is now an enraged bobcat. In a perfect world, I'd agree with your statements. I do not think we have an effective enough understanding of either the compounds we're using, or the systems we're impacting, to be as laissez faire with cocktails as we often are.