In most cases, yes. There are libraries that you might want to use that don't support it yet but the vast majority do. Personally, I'm anxiously waiting for Fab

In most cases, yes. There are libraries that you might want to use that don't support it yet but the vast majority do. Personally, I'm anxiously waiting for Fabric 2 which has been pending for a long time. This is a good resource for figuring out whether the libraries you need are ready: http://py3readiness.org http://py3readiness.org