Mechanisms to think on: 1) Stiffening of tendon tissue via cross-linking and calification. 2) Loss of muscle mass and strength via all of the varied mechanism

Mechanisms to think on: 1) Stiffening of tendon tissue via cross-linking and calification. 2) Loss of muscle mass and strength via all of the varied mechanisms implicated in sarcopenia, ranging from mitochondrial dysfunction to extracellular matrix disruption via cross-links and senescent cells, to fatty infiltration of muscles, diminished stem cell activity, etc, etc. 3) Inefficiency in blood flow to muscles, either through neurological impairment in the normal blood vessel dilation process or through cross-linking and calcification to stiffen blood vessel walls. 4) Dysfunction in cartilage for all the reasons implicated there, such as cross-linking, loss of stem cell function, and so on. There are others, but note that all of these are secondary consequences of types of primary damage that occur as a result of the normal operation of metabolism. They are all targets for repair treatments yet to be constructed.