4 ms·
If you read the article, it has an answer for (b) that so far works in culture and in human tumors inside animal models; Not quite the real thing, but probably
by beagle3 11y ago
If you read the article, it has an answer for (b) that so far works in culture and in human tumors inside animal models; Not quite the real thing, but probably the farthest you can get before human trials, and it is quite far.
With respect to (a) - yes, there are tens or hundreds of fundamentally different cancers. But there's a reason we call them all "cancer" - which is they do have common traits (unchecked growth, glycolisys as the preferred and often singular mode of metabolism - a.k.a the Warburg effect mentioned in the article), so it's not unthinkable that a few bullets could work for significant majority of cancers. It appears that the naked mole rat, a cancer-free rodent[1], has multiple mechanisms against cancer, one of of which is an overcrowding control.
I've read numerous accounts of the usefulness of fasting in fighting cancer (including complete remissions), but no scholarly articles that go far enough. The ignorance about fasting's effects on the human body and how long a relatively person can fast with no irreversible damage (hint: close to 50 days), is quite staggering. The body switches to ketones as an energy source, which the vast majority of cancer cells cannot use. I have found peer reviewed papers showing that fasting makes chemotherapy significantly more effective. It could be your (a) bullet, because it relies on the (b) differentiation.
Wikipedia[0] doesn't list an exact date, but apparently, the Warburg hypothesis dates to around 1920. The Nobel Prize for this discovery was awarded to him in 1931.
I've first read about Warburg and his discovery in 1999, and I asked every MD I met at the time about it - not a single one was aware of it. Somehow, everyone is so specialized today that knowledge that should be common isn't. I assume once a successful therapy based on this effect is developed, though, it will become common knowledge.
[0] https://en.wikipedia.org/wiki/Otto_Heinrich_Warburg https://en.wikipedia.org/wiki/Otto_Heinrich_Warburg
[1] https://en.wikipedia.org/wiki/Naked_mole-rat#Resistance_to_cancer https://en.wikipedia.org/wiki/Naked_mole-rat#Resistance_to_c...