> being overweight is "simply calories in vs calories out" is both trivially true and completely unhelpful I appreciate your overall point, but would argue th

> being overweight is "simply calories in vs calories out" is both trivially true and completely unhelpful I appreciate your overall point, but would argue that the phrase in not necessarily "trivially true" in some cases. Unlike thermodynamics, biology is not simple. A person could potentially die of hunger while also being grossly overweight if they have a problem with certain metabolic genes. If your catabolic enzymes for lipids do not function, you cannot utilize fat or break it down regardless of your overall energy budget. That being said, I doubt that very many people have mutations in the genes for those enzymes, since those variants will tend to be selected out of the population.