4 ms·

So I checked my rs1421085 status and luckily I don't have the obesity variant. I guess the cause of my overweight is my laziness then :)

zrail 11y ago
How did you do this?
- kybernetyk 11y ago
  Got a 23andme analysis some time ago. Now I can just search for gene SNPs (those IDs that start with rs) in the data set and see what variants I have. It's pretty cool.
  - jauer 11y ago
    For the lazy, if you have 23andme and are signed in: https://www.23andme.com/you/explorer/snp/?snp_name=rs1421085 https://www.23andme.com/you/explorer/snp/?snp_name=rs1421085
    - AndrewDucker 11y ago
      Thak you - turns out I have two Cs in there. Fascinating!
    - deleted 11y ago
      [deleted]
    - riemannzeta 11y ago
      Another thanks. Probably the most value I've gotten out of 23andme to date
      - kybernetyk 11y ago
        Try out http://geneticgenie.org/methylation-analysis/ http://geneticgenie.org/methylation-analysis/ It might show you some genetic disorders. As it did for me which I then had confirmed by a doctor. Now I supplement a special form of Folic acid and my homocysteine blood levels are normal (they have been elevated for the last 30 years I guess, wich is not too good).
    - BurningFrog 11y ago
      Thanks! You understand UI design! Not sure if I should be glad I'm not at risk or sad that I don't have that excuse.
tibbon 11y ago
I looked up mine as well. I find it really amazing that we can just look these things up so easily now.
manmal 11y ago
If I read this correctly, and I have genotype CC, then this would mean that I'm at risk, right?
- bdevine 11y ago
  I'm completely unfamiliar with this stuff, but from the article: "In risk individuals, a thymine (T) is replaced by a cytosine (C) nucleobase, which disrupts repression of the control region and turns on IRX3 and IRX5. This then turns off thermogenesis, leading to lipid accumulation and ultimately obesity... Switching the C to a T in risk individuals turned off IRX3 and IRX5, restored thermogenesis to non-risk levels, and switched off lipid storage genes." So yes, CC is taken to mean "risk" and CT is likewise "non-risk". As always, one finding doesn't indicate ultimate truth, so take this all with a grain of salt (or not, depending on what 23andMe has to say about your sodium intake).
  - nether 11y ago
    So TT is lowest risk? That's what I have. I don't really gain weight...
    - toomuchtodo 11y ago
      Damn it, I'm CC. "Switching the C to a T in risk individuals turned off IRX3 and IRX5, restored thermogenesis to non-risk levels, and switched off lipid storage genes." Hurry up CRISPR-CAS9. Need this fixed!
deleted 11y ago
[deleted]
sowhatquestion 11y ago
Mine is CT... does that entail a lower risk?

zrail 11y ago

How did you do this?

kybernetyk 11y ago
Got a 23andme analysis some time ago. Now I can just search for gene SNPs (those IDs that start with rs) in the data set and see what variants I have. It's pretty cool.
- jauer 11y ago
  For the lazy, if you have 23andme and are signed in: https://www.23andme.com/you/explorer/snp/?snp_name=rs1421085 https://www.23andme.com/you/explorer/snp/?snp_name=rs1421085
  - AndrewDucker 11y ago
    Thak you - turns out I have two Cs in there. Fascinating!
  - deleted 11y ago
    [deleted]
  - riemannzeta 11y ago
    Another thanks. Probably the most value I've gotten out of 23andme to date
    - kybernetyk 11y ago
      Try out http://geneticgenie.org/methylation-analysis/ http://geneticgenie.org/methylation-analysis/ It might show you some genetic disorders. As it did for me which I then had confirmed by a doctor. Now I supplement a special form of Folic acid and my homocysteine blood levels are normal (they have been elevated for the last 30 years I guess, wich is not too good).
  - BurningFrog 11y ago
    Thanks! You understand UI design! Not sure if I should be glad I'm not at risk or sad that I don't have that excuse.

tibbon 11y ago

I looked up mine as well. I find it really amazing that we can just look these things up so easily now.

manmal 11y ago

If I read this correctly, and I have genotype CC, then this would mean that I'm at risk, right?

bdevine 11y ago
I'm completely unfamiliar with this stuff, but from the article: "In risk individuals, a thymine (T) is replaced by a cytosine (C) nucleobase, which disrupts repression of the control region and turns on IRX3 and IRX5. This then turns off thermogenesis, leading to lipid accumulation and ultimately obesity... Switching the C to a T in risk individuals turned off IRX3 and IRX5, restored thermogenesis to non-risk levels, and switched off lipid storage genes." So yes, CC is taken to mean "risk" and CT is likewise "non-risk". As always, one finding doesn't indicate ultimate truth, so take this all with a grain of salt (or not, depending on what 23andMe has to say about your sodium intake).
- nether 11y ago
  So TT is lowest risk? That's what I have. I don't really gain weight...
  - toomuchtodo 11y ago
    Damn it, I'm CC. "Switching the C to a T in risk individuals turned off IRX3 and IRX5, restored thermogenesis to non-risk levels, and switched off lipid storage genes." Hurry up CRISPR-CAS9. Need this fixed!

deleted 11y ago

[deleted]

sowhatquestion 11y ago

Mine is CT... does that entail a lower risk?