OS X key shortcuts are very much biased towards alphabetical keys. F-key usage in standard system shortcuts is a very rare thing. In your particular example, re

OS X key shortcuts are very much biased towards alphabetical keys. F-key usage in standard system shortcuts is a very rare thing. In your particular example, reloading is done with Command+R while force reload is Command-Shift-R. Most OS X shortcuts follow this pattern: they're easier to remember (phonetic association) and usually make for less awkward hand positioning when used. Because of this, on my MacBook I've mapped FKeys to do global stuff; F1 brings up Spotlight (launcher), F2 shows a Quake-style drop down terminal, and F3 bring up a popover calendar (Fantastical). The only exception is F4, which ive set up to pop open Xcode's "Quick Open" UI.