[Gwern](https://news.ycombinator.com/user?id=gwern https://news.ycombinator.com/user?id=gwern) has done some interesting self-medication experiments [here](http

[Gwern](https://news.ycombinator.com/user?id=gwern https://news.ycombinator.com/user?id=gwern) has done some interesting self-medication experiments [here](http://www.gwern.net/Modafinil http://www.gwern.net/Modafinil), for Modafinil and [here](http://www.gwern.net/Modafinil http://www.gwern.net/Modafinil), for nicotine. I haven't seen similar reproductions or analyses by other scientists, so peer review (or functional analog) is definitely needed here.