It's not exactly coming out of left field though. PDE4 has been a research topic of much interest over the past decade. There are many studies and review arti

It's not exactly coming out of left field though. PDE4 has been a research topic of much interest over the past decade. There are many studies and review articles talking about the large amount of evidence that PDE4 inhibitors, specifically those that are specific for PDE4B and PDE4D, are excellent cognitive enhancers and possible treatments for neurodegenerative diseases.[1][2] Unfortunately, the PDE4 inhibitor that they used in all the mice studies, Rolipram, causes vomiting in people in very low doses. Thus, there has been a lot of research around trying to find one that works just as well without causing vomiting. These gene tweaking studies just further confirm that these are good drug targets worth spending the lab time on to develop. 1.http://www.ncbi.nlm.nih.gov/pubmed/23883342 http://www.ncbi.nlm.nih.gov/pubmed/23883342 2.http://www.ncbi.nlm.nih.gov/pubmed/25159075 http://www.ncbi.nlm.nih.gov/pubmed/25159075