"Everyone knows what the problem is. It is not that the drugs don't work (well most of them), it is that they only work for a small subset of people." 1. I ho

"Everyone knows what the problem is. It is not that the drugs don't work (well most of them), it is that they only work for a small subset of people." 1. I honestly don't give drug companies that much integrity. 2. Sadly, I feel they systematically lied to the FDA in order to get their product to market? No, I don't think the average pharmaceutical research scientist wanted to poison people, but I have horrid feeling a lot of them went along with the sharade in order to make a living? I picture too many scientists thinking, "Well it doesn't work as we thought, but I'm really not hurting anyone because the Plecebo Effect was huge? So, in order to keep my job, I will not object to these results/statistics?". I have found that when it comes down to a person's livelihood, life--money; people don't raise their hands? They go into this weird, socially acceptable denial?("Hay it's legal!") That's why when even here on HN, I make sure to read the blurry statements.(I'm usually disappointed, but I want to hear the dissenters, and critics.) 3. I'll admit I threw the baby out with the bath water years ago, and I don't have hard evidence (in front of me collated, and ready to provide objective examples) to back up my intuition, and assertions, but I don't think one has to look too far for examples? 4. I grew up not questioning scientific integrity. I thought these institutions/people were the pillars of honesty!; what I have learned in the last decade, specifically about the Pharmacutical Industry, hurt me on so many levels--I literally feel like crying sometimes. 5. My understanding of statistics is fuzzy. To those that need a refresher, I found two books helpful: How to lie with Statistics, by Darrell Huff., and The Comic Book Guide to Statistics--don't know the author.