4 ms·

> Would this explain the propagation of, umm, data-challenged psychiatric drugs in the 80s and 90s? I'm not sure what you're referring to. Could you unpack for

> Would this explain the propagation of, umm, data-challenged psychiatric drugs in the 80s and 90s? I'm not sure what you're referring to. Could you unpack for those of us who haven't followed this but would like to learn?

Alex3917 11y ago
http://www.alexkrupp.com/Citevault.html#pharmaceuticals http://www.alexkrupp.com/Citevault.html#pharmaceuticals See also: http://www.amazon.com/Anatomy-Epidemic-Bullets-Psychiatric-Astonishing/dp/0307452425/ref=pd_sim_14_1?ie=UTF8&refRID=1TPM11KTRTXM9SGBCHJT http://www.amazon.com/Anatomy-Epidemic-Bullets-Psychiatric-A... http://www.amazon.com/Emperors-New-Drugs-Exploding-Antidepressant/dp/0465022006/ref=sr_1_1?ie=UTF8&qid=1439920866&sr=8-1&keywords=the+emperor%27s+new+drugs http://www.amazon.com/Emperors-New-Drugs-Exploding-Antidepre...
- pdabbadabba 11y ago
  I was hoping for some sort of accessible synthesis of the available literature, since I don't have the time or inclination to get eyeballs deep in this issue. But thank you for the links.
duaneb 11y ago
It's hard to explain briefly, and I don't know the details. However, I know that my own antidepressant has no significant difference versus a placebo effect with respect to depression. I'm not claiming that they don't work for people, just that they were rushed to market given current studies. A cursory google search brings up a decent review of the literature here (note, not peer reviewed to my knowledge but an article): http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/
capnrefsmmat 11y ago
Reboxetine is one example. It's an antidepressant pushed by Pfizer. Initial studies showed it was effective versus placebo or SSRIs, but later research found serious publication bias -- Pfizer suppressed evidence suggesting it was not effective. Only after the German Institute for Quality and Efficiency in Health Care obtained unpublished data from Prizer was its lack of efficacy obvious: http://www.bmj.com/content/341/bmj.c4737 http://www.bmj.com/content/341/bmj.c4737 Pre-registration and mandatory publication would help prevent this.

Alex3917 11y ago

http://www.alexkrupp.com/Citevault.html#pharmaceuticals http://www.alexkrupp.com/Citevault.html#pharmaceuticals See also: http://www.amazon.com/Anatomy-Epidemic-Bullets-Psychiatric-Astonishing/dp/0307452425/ref=pd_sim_14_1?ie=UTF8&refRID=1TPM11KTRTXM9SGBCHJT http://www.amazon.com/Anatomy-Epidemic-Bullets-Psychiatric-A... http://www.amazon.com/Emperors-New-Drugs-Exploding-Antidepressant/dp/0465022006/ref=sr_1_1?ie=UTF8&qid=1439920866&sr=8-1&keywords=the+emperor%27s+new+drugs http://www.amazon.com/Emperors-New-Drugs-Exploding-Antidepre...

pdabbadabba 11y ago
I was hoping for some sort of accessible synthesis of the available literature, since I don't have the time or inclination to get eyeballs deep in this issue. But thank you for the links.

duaneb 11y ago

It's hard to explain briefly, and I don't know the details. However, I know that my own antidepressant has no significant difference versus a placebo effect with respect to depression. I'm not claiming that they don't work for people, just that they were rushed to market given current studies. A cursory google search brings up a decent review of the literature here (note, not peer reviewed to my knowledge but an article): http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/

capnrefsmmat 11y ago

Reboxetine is one example. It's an antidepressant pushed by Pfizer. Initial studies showed it was effective versus placebo or SSRIs, but later research found serious publication bias -- Pfizer suppressed evidence suggesting it was not effective. Only after the German Institute for Quality and Efficiency in Health Care obtained unpublished data from Prizer was its lack of efficacy obvious: http://www.bmj.com/content/341/bmj.c4737 http://www.bmj.com/content/341/bmj.c4737 Pre-registration and mandatory publication would help prevent this.