I would say go with Flask specially based on some of the things you said. Let me elaborate: - SQLAlchemy. Flask integrates very well with SQLAlchemy and has a

I would say go with Flask specially based on some of the things you said. Let me elaborate: - SQLAlchemy. Flask integrates very well with SQLAlchemy and has a great extension for it as well (Flask-SQlAlchemy). - "code that's not framework-specific ". Flask is a winner here being micro and you can even build lovely APIs on top of it. - Even though core flask is minimal by design, it now has a matured ecosystem of awesome extensions that lets you rapidly build apps as you need. The beauty is that you are not restricted to one specific way of doing something. Flexibility but that also means you have to make more decisions. Django is great as well but like you said, it is a much bigger framework and more opinionated. Nothing wrong with it but for building large applications, I prefer Flask due to its micro-ness and flexibility.