The only large project using literate programming that I am aware of is Axiom, a symbolic math system written in Lisp. From their documentation it sounds like i

The only large project using literate programming that I am aware of is Axiom, a symbolic math system written in Lisp. From their documentation it sounds like it uses literate programming and would be a good resource. However, a modern version of literate programming is catching on in scientific fields based on Jupyter (IPython) Notebooks. It allows running simulations and embedding results. It's fantastic for exploratory work. The main downside is transitioning code from notebooks to longer term libraries or full applications can be somewhat tricky. Here's a good write up of notebooks and science: http://peterwittek.com/reproducible-research-literate-programming-ipython-and-github.html http://peterwittek.com/reproducible-research-literate-progra...