3 ms·
Thank you for the correction. I mis-remembered a minor detail from a lecture that was 9 years ago, and have find/replaced cAMP -> adenosine in the above post. T
by qiqing 11y ago
Thank you for the correction. I mis-remembered a minor detail from a lecture that was 9 years ago, and have find/replaced cAMP -> adenosine in the above post. The gist of the post, though, remains the same. That is, caffeine competitively inhibits receptors that gate ion channels, and the mechanism of tolerance is an increase in the concentration of the thing that it competitively binds.
(My thesis was on auditory cognition and I haven't touched ion channel biophysics in that long. I have a long-ago memory that adenosine (now corrected) operated as a retrograde transmitter, though since I'm probably not going to spend my afternoon looking for the citations, I'll delete as well for now. Not because I believe it's wrong, just that I can't immediately back it up.)
Are you still doing research yourself or have you left for startup land like most of HN?
- lvs 11y agoThanks for making your corrections as well. Yes, I am in research, and I mostly come here for what's new in Python, learning algorithms, and data analysis. As an aside, it's tough to wade through the "startup land" and personal health advice and keep a straight face in all honesty, but there are few other places that aggregate the things I'm interested in on the computing side of things. An "HN" with users that specialize in bioscience would be very interesting, but I don't know of one with any level of seriousness/activity.
- charles2013 11y agodatatau [0] might be worth checking out, if you're not familiar. since bioscience isn't on my radar i'm not sure if you'd find anything useful there, however, it feels like a more concentrated version of HN which specializes in some of the other stuff that interests you (e.g. learning algos, data analysis, etc.). [0] http://www.datatau.com/ http://www.datatau.com/