4 ms·

neurologists at UCLA Alzheimers center have developed a formulation of Curcumin called "Longvida" which appears to reduce the accumulation of this brain plaque:

by dingbat 11y ago

neurologists at UCLA Alzheimers center have developed a formulation of Curcumin called "Longvida" which appears to reduce the accumulation of this brain plaque: http://alzheimer.neurology.ucla.edu/Curcumin.html http://alzheimer.neurology.ucla.edu/Curcumin.html Curcumin and Alzheimer’s disease. Our group has tested curcumin in several models and found that it not only reduces oxidative damage and inflammation (as expected), but also reduces amyloid accumulation and synaptic marker loss while promoting both amyloid phagocytosis and clearance. In in vitro studies, we found curcumin worked to prevent synaptic marker and cognitive deficits caused by amyloid peptide infusion and abeta oligomer toxicity. Our work on curcumin and AD is discussed in detail in our publications its important to note that it is only the Longvida formulation of Curcumin which effect because it crosses the blood-brain barrier, although other types seem beneficial for other conditions.

will_work4tears 11y ago
It seems more that Curcumin that isn't passed into the kidneys can pass the blood-brain barrier[0], and you can help prevent that by taking it with piperine; most formulations, at least on Amazon, have piperine in it, if it doesn't take it with some black peppercorns. It appears the only difference between most formulations and Longvida is that they pair it with coconut oil? That's what I could gather from their formulation, they don't even list piperine. I'm skeptical of the brand in particular, not in the sense that it's bio-available, but their claim that only their brand crosses the blood-brain barrier[1][2]. [0] a lot of sites mention this in passing, but here's a study that shows 7 days of supplementation crosses the blood-brain barrier, at least in mice: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/ [1] http://news.vanderbilt.edu/2015/01/curcumin%E2%80%99s-ability-to-fight-alzheimer-studied/ http://news.vanderbilt.edu/2015/01/curcumin%E2%80%99s-abilit... [2] http://www.petesplacenutritionalsupplementblog.com/2014/09/curcuwin-curcumin-vs-longvida.html http://www.petesplacenutritionalsupplementblog.com/2014/09/c...

by dingbat 11y ago

will_work4tears 11y ago

It seems more that Curcumin that isn't passed into the kidneys can pass the blood-brain barrier[0], and you can help prevent that by taking it with piperine; most formulations, at least on Amazon, have piperine in it, if it doesn't take it with some black peppercorns. It appears the only difference between most formulations and Longvida is that they pair it with coconut oil? That's what I could gather from their formulation, they don't even list piperine. I'm skeptical of the brand in particular, not in the sense that it's bio-available, but their claim that only their brand crosses the blood-brain barrier[1][2]. [0] a lot of sites mention this in passing, but here's a study that shows 7 days of supplementation crosses the blood-brain barrier, at least in mice: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781139/ [1] http://news.vanderbilt.edu/2015/01/curcumin%E2%80%99s-ability-to-fight-alzheimer-studied/ http://news.vanderbilt.edu/2015/01/curcumin%E2%80%99s-abilit... [2] http://www.petesplacenutritionalsupplementblog.com/2014/09/curcuwin-curcumin-vs-longvida.html http://www.petesplacenutritionalsupplementblog.com/2014/09/c...