From [1]: To our knowledge, only one study investigated the effects of long-term CR (with a diet of reasonable quality) on health and longevity in nonobese hum

From [1]: To our knowledge, only one study investigated the effects of long-term CR (with a diet of reasonable quality) on health and longevity in nonobese humans and a control group (24). This study was conducted in 120 men, of whom 60 were randomly assigned to the control group and 60 to the calorie-restricted group. The control group was fed ≈9600 kJ/d. Calorie-restricted subjects received 1 L milk and 500 g fruit every other day, which led to an overall mean energy intake of ≈6300 kJ/d (or a 35% restriction from the intake of the control group). This regimen was implemented for 3 y. Stunkard (25) reanalyzed these data and reported less time in the infirmary (123 compared with 219 d) and a nonsignificant difference in the death rate (6 compared with 13 deaths) in calorie-restricted subjects than in control subjects, respectively, which suggests that chronic CR may prolong life span in humans. [1] http://ajcn.nutrition.org/content/78/3/361.full http://ajcn.nutrition.org/content/78/3/361.full