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"by actually exercising or practicing calorie restriction" Ever study I've read about has shown that while calorie restriction works in mice, it has no effect

"by actually exercising or practicing calorie restriction" Ever study I've read about has shown that while calorie restriction works in mice, it has no effect in humans.

crusso 11y ago
Actually, calorie restriction has shown to provide life extension in every species tried so far except for one highly over-referenced rhesus monkey study that were contradicted by a later study[1]. Human study results are much more difficult to obtain due to our average life span lengths. Also there was a recent article that made it to the front page of HN talking about a positive study of intermittent fasting's longetivity-related benefits - which is probably a closely related or identical phenomenon (my guess). [1] http://www.nature.com/ncomms/2014/140401/ncomms4557/full/ncomms4557.html http://www.nature.com/ncomms/2014/140401/ncomms4557/full/nco...
gwern 11y ago
> it has no effect in humans. It certainly has documented effects on weight, blood pressure, insulin, etc. What you mean to say is that while it's been amply proven in lower species to extend lifespan, lifespan extension has not been proven in humans as of now.
abrichr 11y ago
From [1]: To our knowledge, only one study investigated the effects of long-term CR (with a diet of reasonable quality) on health and longevity in nonobese humans and a control group (24). This study was conducted in 120 men, of whom 60 were randomly assigned to the control group and 60 to the calorie-restricted group. The control group was fed ≈9600 kJ/d. Calorie-restricted subjects received 1 L milk and 500 g fruit every other day, which led to an overall mean energy intake of ≈6300 kJ/d (or a 35% restriction from the intake of the control group). This regimen was implemented for 3 y. Stunkard (25) reanalyzed these data and reported less time in the infirmary (123 compared with 219 d) and a nonsignificant difference in the death rate (6 compared with 13 deaths) in calorie-restricted subjects than in control subjects, respectively, which suggests that chronic CR may prolong life span in humans. [1] http://ajcn.nutrition.org/content/78/3/361.full http://ajcn.nutrition.org/content/78/3/361.full
intrasight 11y ago
>has no effect in humans This is true in practice for most people. "Calorie restriction" is a misnomer. It should be called "calorie unavailability". Research has show that if the food is there in your fridge but you choose not to eat it, you don't get any benefits. The body and mind have to believe it is starving.
- sleeping_pills 11y ago
  That's very interesting actually. Do you have any links/references for this research?

"by actually exercising or practicing calorie restriction" Ever study I've read about has shown that while calorie restriction works in mice, it has no effect in humans.

crusso 11y ago

Actually, calorie restriction has shown to provide life extension in every species tried so far except for one highly over-referenced rhesus monkey study that were contradicted by a later study[1]. Human study results are much more difficult to obtain due to our average life span lengths. Also there was a recent article that made it to the front page of HN talking about a positive study of intermittent fasting's longetivity-related benefits - which is probably a closely related or identical phenomenon (my guess). [1] http://www.nature.com/ncomms/2014/140401/ncomms4557/full/ncomms4557.html http://www.nature.com/ncomms/2014/140401/ncomms4557/full/nco...

gwern 11y ago

> it has no effect in humans. It certainly has documented effects on weight, blood pressure, insulin, etc. What you mean to say is that while it's been amply proven in lower species to extend lifespan, lifespan extension has not been proven in humans as of now.

abrichr 11y ago

From [1]: To our knowledge, only one study investigated the effects of long-term CR (with a diet of reasonable quality) on health and longevity in nonobese humans and a control group (24). This study was conducted in 120 men, of whom 60 were randomly assigned to the control group and 60 to the calorie-restricted group. The control group was fed ≈9600 kJ/d. Calorie-restricted subjects received 1 L milk and 500 g fruit every other day, which led to an overall mean energy intake of ≈6300 kJ/d (or a 35% restriction from the intake of the control group). This regimen was implemented for 3 y. Stunkard (25) reanalyzed these data and reported less time in the infirmary (123 compared with 219 d) and a nonsignificant difference in the death rate (6 compared with 13 deaths) in calorie-restricted subjects than in control subjects, respectively, which suggests that chronic CR may prolong life span in humans. [1] http://ajcn.nutrition.org/content/78/3/361.full http://ajcn.nutrition.org/content/78/3/361.full

intrasight 11y ago

>has no effect in humans This is true in practice for most people. "Calorie restriction" is a misnomer. It should be called "calorie unavailability". Research has show that if the food is there in your fridge but you choose not to eat it, you don't get any benefits. The body and mind have to believe it is starving.

sleeping_pills 11y ago
That's very interesting actually. Do you have any links/references for this research?